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KMID : 1035620140020020142
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Allergy Asthma & Respiratory Disease
2014 Volume.2 No. 2 p.142 ~ p.145
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Hypersensitivity reaction to aspirin accompanied by severe eosinophilia in a child with history of Kawasaki
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Sol In-Suk
Choi Myung-Hyun
Kim Min-Jung
Kim Yoon-Hee
Lee Hee-Seon
Han Yoon-Ki
Kim Ki-Hwan
Kim Kyung-Won
Sohn Myung-Hyun
Kim Kyu-Earn
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Abstract
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Drug hypersensitivity is one of drug adverse reactions that develop in susceptible patients following exposure to certain drugs and cannot be predicted from the known pharmacology of a drug. Severe hypersensitivity is associated with high morbidity and mortality. Although the issue of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) has been largely investigated in adults, data related to NSAIDs hypersensitivity is insufficient in childhood. And in spite of the recommendation to avoid use of aspirin due to Reye syndrome in children, aspirin is one of major treatment along with intravenous immunoglobulin in Kawasaki disease. We report a case of a 10-month-old boy who underwent intravenous immunoglobulin and aspirin treatment for Kawasaki disease, and subsequently revealed severe leukocytosis and eosinophilia. To our knowledge, there have been no previous reports of aspirin-induced eosinophilia in Korea.
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KEYWORD
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Eosinophilia, Drug hypersensitivity reaction, Aspirin, Kawasaki disease
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